Computer-Aided Drug Design Utilizing Structure Templates Identified by Local Structure Alignment
نویسندگان
چکیده
منابع مشابه
Computer Aided Drug Discovery ( Structure - Based Andligand - Based ) Design
Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the progress of medicine during the past century than any other scientific factor. Computer based drug design is an alternative to the conventional process of drug development. It involves modifying a known drug for new therapeutic indication using computer technology. It...
متن کاملcomputer aided forging design
in forging design the significant parameters are maximum load or energy which are required for the selection of forging press or hammer. these two parameters are varied by the other paramelers such as the geometry of die cavity, flash dimensions, shape of the work piece, friction, mechanical properties of the metal to be forged, temperature, strain rate, and number of the forging operation. the...
متن کاملPotential drug-like inhibitors of Group 1 influenza neuraminidase identified through computer-aided drug design
Pandemic (H1N1) influenza poses an imminent threat. Nations have stockpiled inhibitors of the influenza protein neuraminidase in hopes of protecting their citizens, but drug-resistant strains have already emerged, and novel therapeutics are urgently needed. In the current work, the computer program AutoGrow is used to generate novel predicted neuraminidase inhibitors. Given the great flexibilit...
متن کاملComputer-aided Design and Construction of Glued Laminated Timber Structure
The paper presents the computer-aided design and construction of a large glued laminated timber structure in Aosta, Italy. The structure was completely computer modelled with in-house developed software, which considers both torsion and curvature constraints of timber. Further proprietary software was used to develop, on a plane, the shape of each timber layer without torsion and curvature . Th...
متن کاملAn Overview of Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) in Restorative Dentistry
Objective: To review the current knowledge of CAD/CAM in dentistry and its development in the mentioned field. Sources: An electronic search was conducted across Ovid Medline, complemented by manual search across individual databases, such as Cochrane, Medline and ISI Web of Science databases and Google Scholar for literature analysis on the mentioned topic. The studies were reviewed thoroughly...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.2257